Lab publications - highlights

Developmental origin, functional maintenance and genetic rescue of osteoclasts

Nature 2019, PMID 30971820

- Osteoclasts are of embryonic origin

- Regeneration of osteoclasts through fusion of monocytes with pre-existing osteoclasts

- Genetic rescue of late-onset mouse model of osteopetrosis

Prospective isolation of nonhematopoietic cells of the niche and their differential molecular interactions with HSCs

Blood 2019, PMID 31366622


- Identification of novel molecular regulators of HSC-niche interactions

- Provision of database to determine molecular interactions between any cell populations of mouse and human origin

Comment by Simon Mendez-Ferrer

Kit regulates HSC engraftment across the human-mouse species barrier


Cell Stem Cell 2014, PMID 25017720


- Human HSCs engraft efficiently into adult immune-deficient Kit mutant mice

- Kit mutation enables human HSC engraftment without irradiation conditioning

- Human HSCs show robust multilineage engraftment and self-renewal in mice

CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo


J Expt Med 2015, PMID 26150472


- Transition kinetic through G1 cell cycle phase determines cell fate choices of human HSCs in vivo

- Acceleration of early G1 phase transition results in HSC expansion

- Acceleration of late G1 phase transition results in loss of HSCs

SETD1A protects HSCs from activation-induced functional decline in vivo

Blood 2018, PMID 29348130


- SETD1A regulates DNA damage signaling and repair in HSCs and hematopoietic precursors in the absence of reactive oxygen species accumulation

- SETD1A is important for the survival of mice after inflammation-induced HSC activation in situ

Comment by Isabel Beerman

CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages

Nature Communications 2019, PMID 30538245


- The pool size of dendritic cells in the spleen is determined by embryo-derived macrophages during development

- Regeneration of activation-induced depleted dendritic cells depends on embryo-derived red-pulp macrophages

Complete list, publications of the lab

Rasoulouniriana D, Santana-Magal N, Gutwillig A, Farhat-Younis L, Tal L, Amar S, Milyavsky M, Muddineni SSNA, Solomon N, Shpilt H, Dotan S, Pilpel N, Waskow C, Feinmesser M, Rider P, Carmi Y. 2023 T cells expressing a modified FcgRI exert antibody-dependent cytotoxicity and overcome the limitations of CAR T-cell therapy against solid tumors. Cancer Immunol Res, doi:10.1158/2326-6066. IF10

Foßelteder J, Pabst G, Sconocchia T, Schlacher A, Auinger L, Kashofer K, Beham-Schmid C, Trajanoski S, Waskow C, Schöll W, Still H, Zebisch A, Wölfler A, Thomas D, Reinisch A. 2023 Human gene-engineered calreticulin mutant stem cells recapitulate MPN hallmarks and identify targetable vulnerabilities. Leukemia, doi:10.1038/s41375-023-01848-6. IF12.9

Cossarizza A, ... Percin G, ... Waskow C, ... 2021 Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition), Eur J Immunol, 51(12):2708-3145. IF4.4

Goveas N, Waskow C, Arndt K, Heuberger J, Zhang Q, Alexopoulou D, Dahl A, Birchmeier W, Anastassiadis K, Stewart AF, Kranz A. 2021 MLL1 is required for maintenance of intestinal stem cells. PLoS Genet. doi:10.1371/journal.pgen.1009250.

Fröbel J, Landsperky T, Percin G, Schreck C, Rahmig S, Ori A, Nowak D, Essers M, Waskow C*, Oostendorp RAJ*. 2021 The Hematopoietic Bone Marrow Niche Ecosystem. Front Cell Dev Biol doi:10.3389/fcell.2021.705410. *co-supervision

Coppin E*, Sundarasetty BS*, Rahmig S, Blume J, Verheyden NA, Bahlmann F, Ravens S, Schubert U, Schmid J, Ludwig S, Geissler K, Guntinas-Lichius O, von Kaisenberg C, Groten T, Platz A, Naumann R, Ludwig B, Prinz I, Waskow C**, and Krueger A**. 2021 Enhanced Differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7. Leukemia doi:10.1038/s41375-021-01259-5. IF8.7, *equal contribution, **co-supervised the study

Jayavelu AK, Schnöder TM, Perner F, Herzog C, Meiler A, Krishnamoorthy G, Huber N, Mohr J, Edelmann-Stephan B, Austin R, Brandt S, Palandri F, Schröder N, Isermann B, Edlich F, Sinha AU, Ungelenk M, Hübner CA, Zeiser R, Rahmig S, Waskow C, Coldham I, Ernst T, Hochhaus A, Tilg S, Jost PJ, Mullally A, Bullinger L, Mertens PR, Lane SW, Mann M, Heidel FH. 2020 Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms. Nature, doi:10.1038/s41586-020-2968-3, IF41.6

Weinberger T*, Esfandyari D*, Messerer D*, Percin G*, Schleifer C*, Thaler R*, Lui L,  Stremmel C, Schneider V, Vagnozzi RJ, Schwanenkamp J, Fischer M, Busch K, Klapproth K, Ishikawa-Ankerhold H, Klösges L, Titova A, Moklentin JD, Kobayashi Y, Engelhardt S, Massberg S, Waskow C, Perdiguero EG, Schulz C. 2020 Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation. Nature Communincations 11;11(1):4549. IF11.9,  *equal contribution


Cossarizza A, ... Rahmig S, ... Waskow C, ... 2019 Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition), Eur J Immunol, 49(10):1457-1973. IF4.6


Mende N, Jolly A, Percin GI, Gunther M, Rostovskaya M, Krishnan SM, Oostendorp RAJ, Dahl A, Anastassiadis K, Hofer T, and Waskow C. 2019 Prospective isolation of non-hematopoietic cells of the niche and their differential molecular interactions with HSCs. Blood, 134(15):1214-1226. IF16.6


Kolter J, Feuerstein R, Zeis P, Hagemeyer N, Paterson N, d'Errico P, Baasch S, Amann L, Masuda T, Lösslein An Gharun K, Mezer-Luehmann M, Waskow C, Franzke CW, Grün D, Lämmermann T, Prinz M, and Henneke P. 2019 A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves. Immunity, 50(6):1482-1497. IF19.7


Garg S, Reyes-Palomares A, He L, Bergeron A, Lavallee VP, Lemieux S, Gendorn P, Rohde C, Xia J, Jagdhane P, Müller-Tidow C, Lipka DB, Imren S, Humphries RK, Waskow C, Vick B, Jeremias I, Richard-Carpentier G, Hebert J, Sauvageau G, Zaugg JB, Barabe F, and Pabst D. 2019 Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML. Blood, 18;134(3):263-267. IF15.1


Günes C, Paszowski-Rogacz M, Rahmig S, Khattak S, Camgöz A, Wermke M, Dahl A, Bornhäuser M, Waskow C, and Buchholz F. 2019 Comparative RNAi Screens in Isogenic Human Stem Cells Reveal SMARCA4 as a Differential Regulator. Stem Cell Reports, 14;12(5):1084-1098. IF6.5


Jacome-Galarza CE*, Percin GI*, Mueller JT*, Mass E*, Lazarov T, Eitler J, Rauner M, Yadav V, Crozet L, Bohm M, Karsenty G, Waskow C**, and Geissmann F**. 2019 Developmental origin and functional maintenance of osteoclasts. Nature,

*same contribution first author,  **co-supervised the study, IF41.6


Muller TA, Pennisi S, Zwick A, Decker S, Klein C, Rister B, Rudorf A, Kissel S, Follo M, Wasch R, Illert AL, Pfeifer D, Oostendorp R, Waskow C, Dierks C, Duyster J. 2019 PIM1 inhibition effectively enhances plerixafor-induced HSC mobilization by counteracting CXCR4 upregulation and blocking CXCL12 secretion. Leukemia doi10.1038/s41375/019/0428/6. IF10


Percin GI, Eitler J, Kranz A, Fu J, Pollard JW, Naumann R, and Waskow C. 2018 CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages. Nature Communications, 11;9(1):5279. IF12.4

Frobel J, Rahmig S, Franzen J, Waskow C, and Wagner W. 2018 Epigenetic aging of human hematopoietic cells is not accelerated upon transplantation into mice. Clin Epigenetics, 22;10:67. IF5.5


Arndt K, Kranz A, Fohgrub J, Jolly A, Bledau AS, Di Virgilio M, Lesche M, Dahl A, Höfer T, Stewart AF, and Waskow C. 2018 SETD1A protects HSCs from activation-induced functional decline in vivo. Blood, 131(12):1311-1324, PMID 29348130. IF13

Chen Y, Anastassiadis K, Kranz A, Stewart AF, Arndt K, Waskow C, Yokoyama A, Jones K, Neff T, Lee Y, and Ernst P. 2017 MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia. Cancer Cell, 31(6):755-770, PMID 28609655, IF27

Schreck C, Istvanffy R, Ziegenhain C, Sippenhauer T, Ruf F, Henkel L, Gaertner F, Vieth B, Florian MC, Mende N, TAubenberger A, Prendergast A, Wagner A, Pagel C, Grziwok S, Goetze KS, Guck J, Dean DC, Massberg S, Essers M, Waskow C, Geiger H, Schiemann M, Peschel C, Enard W, Oostendorp RA. 2016 Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells. J Exp Med, PMID 27998927, IF14

Bigas A and Waskow C. 2016. Blood stem cells: from beginning to end. Development. 143(19):3429-3433, Review, PMID 27702782. IF6

Rahmig S, Kronstein-Wiedemann R, Fohgrub J, Kronstein N, Nevmerzhitskaya A, Bornhäuser M, Gassmann M, Platz A, Ordemann R, Tonn T, and Waskow C. 2016. Improved human erythropoiesis and platelet formation in humanized NSGW41 mice. Stem Cell Reports, 11:7(4):591-601. IF7

Schoedel KB, Morcos MN, Zerjatke T, Roeder I, Grinenko T, Voehringer D, Gothert JR, Waskow C, Roers A, and Gerbaulet A. 2016. The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis. Blood, PMID 27357698. IF12

Kolter J, Feuerstein R, Spoeri E, Gharun K, Elling R, Trieu-Cuot P, Goldmann T, Waskow C, Chen ZJ, Kirschning CJ, Deshmukh SD, and Henneke P. 2016. Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion. J Immunol 15:196(6):2733-2741. IF5

Kourtzelis I, Kotlabova K, Lim JH, Mitroulis I, Ferreira A, Chen LS, Gercken B, Steffen A, Kemter E, Klotzsche-von Ameln A, Waskow C, Hosur K, Chatzigeorgiou A, Ludwig B, Wolf E, Hajishengallis G, and Chavakis T. 2015. Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation. Thrombosis and haemostasis 115: 33-39. IF5

Mende N, Kuchen E, Lesche M, Grinenko T, Kokkaliaris Kd, Hanenberg H, Lindemann D, Dahl A, Platz A, Hoefer T, Calegari F, Waskow C. 2015. Ccnd1/Cdk4-mediated cell cycle progression provides a competitive advantage for human hemantopoietic stem cells in vivo. J Exp Med; 212(8):1171-1183. IF14


Daenthanasanmak A, Salguero G, Sundarasetty BS, Waskow C, Cosgun KN, Guzman CA, Riese P, Gerasch L, Schneider A, Ingendoh A, Messerle M, Gabaev I, Woelk B, Ruggiero E, Schmidt E, von Kalle C, Figueiredo C, Eiz-Vesper B, von Kaisenberg C, Ganser A, and Stripecke R. 2015. Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV. Mol Ther Methods Clin Dev 1:14060. IF7

Kourtzelis I, Ferreira A, Mitroulis I, Ricklin D, Bornstein SR, Waskow C, Lambris JD, and Chavakis T, 2015. Complement inhibition in a xenogeneic model of interactions between human whole blood and porcine endothelium. Horm. Metab. Res. 47:36-42. IF2

Muller E, Grinenko T, Pompe T, Waskow C, and Werner C, 2015. Space constraints govern fate of hematopoietic stem and progenitor cells in vitro. Biomaterials 53:709-715. IF8

Rahmig S, Bornstein SR, Chavakis T, Jaeckel E, and Waskow C, 2015. Humanized mouse models for type 1 diabetes including pancreatic islet transplantation. Horm. Metab. Res 47:43-47. IF 2

Cosgun* KN, Rahmig* S, Mende N, Reinke S, Hauber I, Schäfer C, Petzold A, Weisbach H, Heidkamp G, Purbojo A, Cesnjevar R, Platz A, Bornhäuser M, Schmitz M, Dudziak D, Hauber J, Kirberg J, Waskow C, 2014. Kit Regulates HSC Engraftment across the Human-Mouse Species Barrier. Cell Stem Cell, 15:227-238. *Co-first authors. IF26

Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun KN, Alexopoulou D, Lakshmanaperumal N, Henry I, Dahl A, Waskow C, 2014. Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells. J Exp Med. 211:209-215. IF 14

Prewitz M, Seib PF, von Bonin M, Niehae C, Friedrichs J, Stißel A, Müller K, Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C. 2013. Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments. Nature Methods. 10:788-794. IF 26

Singh RP, Franke K, Kalucka J, Mamlouk S, Mutschter A, Gembarska A, Grinenko T, Willam C, Naumann R, Anastassiadis K, Stewart AF, Bornstein S, Chavakis T, Breier G, Waskow C, Wielockx B. 2013 HIF-prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress. Blood, 121:5158-5166. IF10

Von Bonin M, Wermke M, Cosgun KN, Thiede C, Bornhauser M, Wagemaker G, Waskow C. 2013 In vivo expansion of co-transplanted T cells impacts on tumor re-initiating activity of human acute myeloid leukemis in NSG mice. PLoS One. 8:e60680. Doi: 10.1371. IF4

Arndt K, Grinenko T, Mende N, Reichert D, Portz M, Ripich T, Carmeliet P, Corbeil D, Waskow C. 2013 CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells. Proc Natl Acad Sci U S A. 110:5582-5587. IF10

Ross K, Sedello AK, Todd GP, Paszkowski-Rogacz M, Bird AW, Ding L, Grinenko T, Behrens K, Hubner N, Mann M, Waskow C, Stocking C, and Buchholz F. 2012. Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells. Blood 119:4152-4161. IF10

Dudeck A, Dudeck J, Scholten J, Petzold A, Surianarayanan S, Kohler A, Peschke K, Vohringer D, Waskow C, Krieg T, Muller W, Waisman A, Hartmann K, Gunzer M, and Roers A. 2011. Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens. Immunity. 34:973-84. IF24

Gerbaulet A, Wickenhauser C, Scholten J, Peschke K, Drube S, Horny HP, Kamradt T, Naumann R, Muller W, Krieg T, Waskow C, Hartmann K, and Roers A. 2011 Mast cell hyperplasia, B cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit. Blood. 117:2012-2021. IF11

Waskow C, Madan V, Bartels S, Costa C, Blasig R, and Rodewald HR. 2009 Hematopoietic stem cell transplantation without irradiation. Nat Methods. 6:267-9. IF17

Waskow C, Liu K, Darrasse-Jeze G, Guermonprez P, Ginhoux F, Merad M, Shengelia T, Yao K, and Nussenzweig M. 2008 The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol. 9:676-83. IF25

Liu K, Waskow C, Liu X, Yao K, Hoh J, and Nussenzweig M. 2007 Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol. 8:578-83. IF26

Waskow C, Bartels S, Schlenner SM, Costa C, and Rodewald HR. 2007 Kit is essential for PMA-inflammation-induced mast-cell accumulation in the skin. Blood. 109:5363-70. IF11

Stumpf M, Waskow C, Krotschel M, van Essen D, Rodriguez P, Zhang X, Guyot B, Roeder RG, and Borggrefe T. 2006. The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Proc Natl Acad Sci U S A. 103:18504-9. IF10

Terszowski G, Waskow C, Conradt P, Lenze D, Koenigsmann J, Carstanjen D, Horak I, and Rodewald HR. 2005 Prospective isolation and global gene expression analysis of the erythrocyte colony-forming unit (CFU-E). Blood. 105:1937-45. IF10

Kroll J, Shi X, Caprioli A, Liu HH, Waskow C, Lin KM, Miyazaki T, Rodewald HR, and Sato TN. 2005 The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation. Mol Cell Biol. 25:8531-40. IF6

Agosti V, Corbacioglu S, Ehlers I, Waskow C, Sommer G, Berrozpe G, Kissel H, Tucker CM, Manova K, Moore MA, Rodewald HR, and Besmer P. 2004 Critical Role for Kit-mediated Src Kinase But Not PI 3-Kinase Signaling in Pro T and Pro B Cell Development. J Exp Med. 199:867-878. IF16

Waskow C, Terszowski G, Costa C, Gassmann M, and Rodewald HR. 2004 Rescue of lethal c-KitW/W mice by erythropoietin. Blood. 104:1688-95. IF10

Waskow C, Paul S, Haller C, Gassmann M, and Rodewald HR. 2002 Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis. Immunity. 17:277-88. IF17

Rodewald HR, Waskow C, and Haller C. 2001 Essential requirement for c-kit and common gamma chain in thymocyte development cannot be overruled by enforced expression of Bcl-2. J Exp Med. 193:1431-7. IF15

Rodewald HR, Ogawa M, Haller C, Waskow C, and DiSanto JP. 1997 Pro-thymocyte expansion by c-kit and the common cytokine receptor gamma chain is essential for repertoire formation. Immunity. 6:265-72. IF21